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Characterization of Mucilages from Abelmoschus Manihot Linn., Amaranthus Spinosus Linn. and Talinum Triangulare (Jacq.) Willd. Leaves for Pharmaceutical Excipient Application

2, 2

  1. 1Jr Department of Chemistry, College of Arts and Sciences, Central Mindanao University, Musuan, Bukidnon, PHILIPPINES.
  2. 2Department of Chemistry, College of Arts and Sciences, Central Mindanao University, Musuan, Bukidnon, PHILIPPINES.

CORRESPONDENCE

Aileen May Gabule Ang

Department of Chemistry, College of Arts and Sciences, Central Mindanao University, Musuan, Bukidnon, PHILIPPINES.

aisemg_ang@yahoo.com

Received: 20-12-2018; Accepted: 17-04-2019.

Volume 8, Issue 1 · pp. 16-24 · 2019 · DOI: 10.5530/ajbls.2019.8.3

ABSTRACT

Introduction: The edible leaves of Abelmoschus manihot Linn., Amaranthus spinosus Linn., and Talinum triangulare (Jacq.) Willd. are exhibiting mucilaginous features and are utilized in making soupy dishes. However, the utilization of the said plant species as sources of mucilages for pharmaceutical excipient application has not yet been reported in the literature.Objectives: The study aimed to extract and partially characterize mucilages from the leaves of A. manihot, A. spinosus, and T. triangulare for potential pharmaceutical excipient application.Materials and Methods: Mucilages were extracted from the leaves of A. manihot, A. spinosus, and T. triangulare. Preliminary qualitative tests as well as determination of the physico-chemical properties, i.e., pH, solubility, swelling index, loss on drying, total sugar content, and total uronic acid content, were conducted on the extracted mucilages. Identification of functional groups was also carried out through Fourier Transform Infrared (FTIR) spectroscopy. Results and Discussion: Results of the qualitative tests showed detection of carbohydrates, polysaccharides, and mucilages among the mucilages extracted from A. manihot, A. spinosus, and T. triangulare. The pH values of the extracted mucilage were nearly neutral, indicating that they can be less irritating to the gastrointestinal tract when utilized for tablet formulations. Data obtained for the physico-chemical properties showed that mucilages of A. manihot gave statistically different values as compared to the mucilages derived from A. spinosus and T. triangulare. A. manihot mucilage exhibited a significantly higher swelling index (357.78%) and total sugar content (273.65 mg glucose/g extract) and a significantly lower loss on drying (10.72%) and total uronic acid content (105.20 mg glucuronic acid/g extract) than the other mucilages from A. spinosus and T. triangulare. Furthermore, FTIR spectral analysis showed typical peaks and characteristic bands of mucilage.Conclusion: A. manihot mucilage is promising for utilization as a pharmaceutical excipient. However, further analysis is recommended.

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    Ang, A. M. G., & Jr, I. C. R. (2019). Characterization of Mucilages from Abelmoschus Manihot Linn., Amaranthus Spinosus Linn. and Talinum Triangulare (Jacq.) Willd. Leaves for Pharmaceutical Excipient Application. Asian Journal of Biological and Life Sciences, 8(1), 16-24. https://doi.org/10.5530/ajbls.2019.8.3

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    © 2019 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0