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Trianthema decandra Root Extract and Cisplatin Action on Biochemical and Histological Characterization of Oral Cancer in DMBA-induced Preclinical Hamster Model

1, 1,2, 3, 1, 1, 1

  1. 1Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA.
  2. 2Department of Biochemistry, Government Arts College (Autonomous), Kumbakonam, Tamil Nadu, INDIA.
  3. 3Department of Biochemistry, Government Arts College, Paramakudi, Tamil Nadu, INDIA.

CORRESPONDENCE

Ganapathy Sindhu

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA.

ganapathysindhu@gmail.com

Received: 19-06-2023; Revised: 14-07-2023; Accepted: 15-08-2023.

Volume 12, Issue 2 · pp. 253-262 · 2023 · DOI: 10.5530/ajbls.2023.12.35

ABSTRACT

Aim: Chemoprevention, an emerging promising technique for experimental oncology, focuses on the use of natural extracts to inhibit or prevent the progression of malignancy. In this study, the chemopreventive ability of TD (Trianthema decandra) root extract was studied in regard to DMBA-induced HBPs.Materials and Methods: The left buccal pouches were painted with a mixture of 0.5% DMBA in liquid paraffin weekly thrice for 14 weeks, and the result was the development of buccal cancer. In hamsters given two treatments, DMBA alone or DMBA+TD root extract, tumor development measurement, detoxification agents, Lipid Peroxidation (LPO), antioxidant status, renal function markers, and histological alterations were evaluated.Results: Hamsters provided the treatment demonstrated 100% tumor occurrences with DMBA alone, which causes an imbalance in the enzymes that break up carcinogens, renal function identifiers, and cellular redox state. When administered orally to hamsters undergoing DMBA medication, TD root extract entirely prevented the formation of tumors and improved the cellular redox state and the activity of enzymes that break down carcinogens.Conclusion: TD root extract may be used as a conventional medicine for rejuvenating and nephrogenic remedies and shows promising chemopreventive efficacy in DMBA-induced HBPs cancer.

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    Porkodi, M., Sindhu, G., Asha, K. R. T., Vinothkumar, V., Pugalendi, P., & Vaitheeswari, B. (2023). Trianthema decandra Root Extract and Cisplatin Action on Biochemical and Histological Characterization of Oral Cancer in DMBA-induced Preclinical Hamster Model. Asian Journal of Biological and Life Sciences, 12(2), 253-262. https://doi.org/10.5530/ajbls.2023.12.35

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    © 2023 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0