Article · Volume 9, Issue 3 · pp. 302-305

Cytotoxic Effects of Luteolin Isolated from Feronia limonia Linn.

Jayashree Hanchinalmath¹, Ramesh Londonkar¹, Kirankumar Shivasharanappa²

¹Department of Biotechnology, Gulbarga University, Gulbarga, Karnataka, INDIA.
²Department of Life Sciences, Garden City University, Bengaluru, Karnataka, INDIA.

Abstract

Aim: To evaluate cytotoxic properties of Feronia limonia Linn. in different test systems.Methods: In the present study, we have evaluated germination of green grams, viability of yeasts, and potato disc assay for rapid and inexpensive screening of drugs exhibiting cytotoxic properties of the isolated compound in comparison with the standard drug. Seed germination parameters—rootlet growth and inhibition—were assayed. Yeast viability was assessed by spectrophotometric and methylene blue staining methods.Results: Zone of inhibition studies against Agrobacterium tumefaciens and potato disc assay have shown a distinct interference of plant extracts against tumor formation and bacterial growth, thereby attributing to antitumor and growth inhibitor properties.Conclusion: This screening test helps in identifying potential plant types that can be used for medicinal purposes against specific microbes and also as a nutritional supplement for fighting against free oxide radicals.

Keywords: Agrobacterium tumefaciens; Herbal extracts; Potato disc; Seed germination; Yeast

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