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Optimization of Statin Production from Aspergillus tamarii

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  1. 1Dr. GR Damodaran College of Science, School of Biotechnology, Coimbatore, Tamil Nadu, INDIA.

CORRESPONDENCE

Suganthi Ramasamy

Dr. GR Damodaran College of Science, School of Biotechnology, Coimbatore, Tamil Nadu, INDIA.

sugantham2000@gmail.com

Received: 12-06-2020; Accepted: 30-08-2020.

Volume 9, Issue 2 · pp. 214-219 · 2020 · DOI: 10.5530/ajbls.2020.9.33

ABSTRACT

The present investigation was focused on screening of Lovastatin production using different agro-based wastes and augment the lovastatin production by isolating Aspergillus tamarii using response surface methodology (RSM) conducting statistical design such as Plackett - Burman design (PB) and Box - Behnken design (BB). Substrates such as rice husk, wheat bran, corn and sorghum bran were initially screened for evaluation of effective lovastatin production using Aspergillus tamarii under solid state fermentation (SSF). Among different substrates, wheat bran was the best substrate for lovastatin production proving highest yield of statin was 100 μg/ml. Further with submerged fermentation, the yield of statin was 96 μg/ml when glucose and lactose were used as a substrate. Thus, Aspergillus tamarii has the potential to be the source of statin production and can be used in different therapeutic applications.

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    Anilkumar, N. K., Krishna, A. R., Chockalingam, J., Balakrishnan, L., Janarthanan, N. T., Ramachandran, P., Palanisami, S. D., Dhanaraj, S. S., Joseph, S., Jayalekshmi, S. K., Antony, T. M. P., & Ramasamy, S. (2020). Optimization of Statin Production from Aspergillus tamarii. Asian Journal of Biological and Life Sciences, 9(2), 214-219. https://doi.org/10.5530/ajbls.2020.9.33

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    © 2020 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0