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AJBLS · Lens · Influence of Body Weight and Body Mass Index (BMI) on Serum Creatinine and Creatinine Clearance in Apparently Healthy Adults

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Article · Volume 2, Issue 3 · pp. 264-269

Influence of Body Weight and Body Mass Index (BMI) on Serum Creatinine and Creatinine Clearance in Apparently Healthy Adults

Festus, O. O.1, Ovie, E. G.1, Osadolor, H. B.2, Ihongbe, J. C.3, Osagie, E. V.4, Unuabonah, F. H.1, Eidangbe A. P.1

  1. 1Department of Medical Laboratory Science, College of Medicine, Ambrose Alli University, Ekpoma, Edo state, NIGERIA.
  2. 2Department of Medical Laboratory Science, College of Medicine, University of Benin, Ugbowo, Edo state, NIGERIA.
  3. 3Dept. of Med. Lab.Science, Faculty of Pure and Allied Sciences, Babcock University, Ileshan-Remo, Ogun State, NIGERIA.
  4. 4Dept. of Biochemistry, Faculty of Natural Sciences, Ambrose Alli University, Ekpoma, NIGERIA.

Abstract

Serum creatinine and creatinine clearance are widely used clinically as an index of renal function to diagnose, treat and follow up renal diseases. One of the factors influencing the creatinine and its clearance is said to be body weight. To evaluate the influence of body weights on serum creatinine and creatinine clearance, a total of 160 healthy adult subjects (68 males and 92 females), within 1845 years of age were included in this study. The subjects were categorized according to body mass index (BMI): 30 kg/m2 (obese) consisting of 40 subjects respectively. Serum and 2hr urine samples were obtained from all subjects and analyzed using the alkaline picrate method. Astatistical significant difference (P0.05). Also, serum creatinine and creatinine clearance among females of various weight were found to be significantly different (P<0.05). Also, values observed for males were higher than those of females. This study thus shows that body weight and BMI have significant influence on serum creatinine and creatinine clearance.

Keywords: Influence; Serum; Creatinine; Healthy

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