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Review

Unveiling Tigliane Derivatives as Novel Therapeutics for Alzheimer's Disease

1, 2, 3, 1

  1. 1Department of Pharmaceutical Technology, Brainware University, Barasat, Kolkata, West Bengal, INDIA.
  2. 2Department of Pharmaceutical Chemistry, School of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, INDIA.
  3. 3Department of Pharmaceutical Technology, Maulana Abul Kalam Azad University of Technology, West Bengal, Nadia, West Bengal, INDIA.

CORRESPONDENCE

Kausik Bhar

Department of Pharmaceutical Technology, Brainware University, Barasat, Kolkata, West Bengal, INDIA.

kausikchemistry@gmail.com

Received: 14-07-2025; Revised: 03-09-2025; Accepted: 24-11-2025.

Volume 14, Issue 3 · pp. 532-540 · 2026 · DOI: 10.5530/ajbls.20250029

ABSTRACT

Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder with limited therapeutic options. Current treatments offer only symptomatic relief without halting disease progression. Natural products and their derivatives have garnered increasing interest for neuroprotection. Among them, tigliane diterpenoids, primarily derived from the Euphorbiaceae family, have shown potent biological activities, including anti-inflammatory, antioxidant, and neuroprotective properties. This review examines the therapeutic potential of tigliane derivatives in the treatment of Alzheimer's disease, concentrating on their pharmacological effects, molecular mechanisms, and structure-activity relationships. Furthermore, we discuss challenges and prospects of tigliane-based drug development as novel interventions for AD.

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    Bhar, K., Mondal, S., Ali, K. A., & Samajdar, S. (2026). Unveiling Tigliane Derivatives as Novel Therapeutics for Alzheimer's Disease. Asian Journal of Biological and Life Sciences, 14(3), 532-540. https://doi.org/10.5530/ajbls.20250029

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    © 2026 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0