A Comparative Study on the in vitro Cytotoxicity and Anti-Cancer Properties of Gold Nanoparticles Derived from Elettaria cardamomum

ABSTRACT

Aim: This study scrutinizes the anti-cancer potential of gold nanoparticles derived from Elettaria cardamomum pods and seeds.Materials and Methods: The biosynthesized nanoparticles underwent thorough characterization via UV Vis, FTIR, SEM, and EDX analyses. Utilizing the MTT assay, cytotoxicity and anti-cancer efficacy against L929 (normal fibroblast) and colon cancer cell lines (HT-29 and SW480) were assessed.Results: Notably, the IC50 values for pod- and seed-based nanoparticles were determined as 156.12 μg/mL and 48.771 μg/mL, respectively, against L929 cells. Strikingly, Elettaria cardamomum pod-based nanoparticles demonstrated superior anti-cancer potential against HT-29 and SW480 cell lines compared to seed-based counterparts.Conclusion: Therefore, this study suggests the potential therapeutic utility of green-synthesized gold nanoparticles from Elettaria cardamomum pods as an innovative approach for treating colorectal cancer.

KEYWORDS

• Anti-cancer
• Colorectal cancer
• Cytotoxicity
• Elettaria cardamomum
• Gold nanoparticles

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• DOI10.5530/ajbls.2024.13.14Copy

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© 2024 Author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0

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