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Prospective Role of Unani Pharmacopeial Formulation Safoof Hijrul Yahood in Preventing Recurrence of Nephrolithiasis: An Open Labeled Clinical Study

1, 1, 1, 3, 1, 1, 1, 2, 1

  1. 1Research Officer, Regional Research Institute of Unani Medicine, Srinagar, Jammu and Kashmir, INDIA.
  2. 2Regional Research Institute of Unani Medicine, New Delhi, INDIA.
  3. 3School of Unani Medical Education and Research, Jamia Hamdard, New Delhi, INDIA.

CORRESPONDENCE

Shaista Urooj

Regional Research Institute of Unani Medicine, New Delhi, INDIA.

shaistaccrum@gmail.com

Received: 14-02-2023; Revised: 11-03-2023; Accepted: 17-03-2023.

Volume 12, Issue 1 · pp. 144-150 · 2023 · DOI: 10.5530/ajbls.2023.12.20

ABSTRACT

Background: The recurrence of nephrolithiasis has a high incidence in the northern region of India, posing major health problems.Aim and Objectives: To study the efficacy of the Unani pharmacopeial formulation Safoof Hajrul Yahood (SHY) in preventing the recurrence of nephrolithiasis. Study Design: Open-labeled, single-arm, clinical trial.Materials and Methods: The study was conducted on 75 cases of uncomplicated nephrolithiasis (Hisat al Kuliya). The post-trial assessment was done on 49 cases after five years. Subsequent to written and informed consent, patients of all genders between 18-60 years with 6-8mm calculi were given SHY (5g twice daily orally for 8 weeks). Patients were followed up fortnightly, investigated at days 0, 15, and 60, and enquired about their diet and fluid intake. The data were analyzed using the Tukey-Kramer multiple comparison test and paired t-test.Results: The mean age of patients was 33.45 ± 10.99 years, CI (30.92-35.99). SHY reduced 24-hour calcium excretion highly significantly (p < 0.0001). The calculus clearance rate was 64%, and recurrence after five years was 29.16%. The drug was well tolerated.Conclusion: SHY probably corrects crystalloid-colloidal imbalance or the oxalate metabolism and/or renal functions, thus preventing recurrence. However, the exact mechanism of the drug needs to be studied.

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    Shah, A., H, H., Iqbal, A., Jahangir, U., Shah, K., S, S., Hanga, A. H., Urooj, S., & Rafiqi, T. (2023). Prospective Role of Unani Pharmacopeial Formulation Safoof Hijrul Yahood in Preventing Recurrence of Nephrolithiasis: An Open Labeled Clinical Study. Asian Journal of Biological and Life Sciences, 12(1), 144-150. https://doi.org/10.5530/ajbls.2023.12.20

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    © 2023 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0