Study of the Effects of Various Polyphenols on Proliferative Processes and the Functional State of Liver Mitochondria of Experimental Toxic Hepatitis

Abstract

Background: Toxic hepatitis is considered one of the most serious concerns in health care because it can lead to the development of liver cirrhosis and primary liver cancer.Materials and Methods: In this work, models of toxic hepatitis animals were prepared, and the effects of various polyphenols on the liver mitochondria of the model animals were studied. For this, liver mitochondria of the animals were isolated, and the lipid peroxidation, the respiration rate and parameters of oxidative phosphorylation, the activity of enzymes of the respiratory chain, and mitochondrial protein synthesis were determined.Results: It was found that the studied plant-origin polyphenols, rutan and hetasan, showed antioxidative properties. It was shown that these polyphenols exert a stabilizing influence on the decreased functional conditions of liver mitochondria in the case of toxic hepatitis by stimulating energy-producing function, the activity of oxidative chain enzymes, and mitochondrial protein synthesis. During the investigations of the polyphenols’ antiproliferative abilities, it was found that rutan is characterized by considerable antifibrotic activity.Conclusion: The plant polyphenols rutan and hetasan are hepatoprotectors with pronounced therapeutic effects in toxic hepatitis. In this study, it was determined that the therapeutic effect of these polyphenols includes an improvement of energy metabolism, a decrease in the process of lipid peroxidation of mitochondrial membranes, as well as the proliferation of fibrous tissue in the liver parenchyma. This may occur due to the antioxidant activity of the polyphenols.

Keywords: Functional state; Polyphenols; Proliferative processes; Toxic hepatitis.