Preliminary Larvicidal Potential of Andrographis Echioides against Dengue Vector Aedes aegypti Larvae
1, 1, 1, 2, 3
- 1Department of Pharmacology, Nandha College of Pharmacy, Erode, Tamil Nadu, INDIA.
- 2Department of Animal Nutrition, Veterinary College and Research Institute, Namakkal, Tamil Nadu, INDIA.
- 3Department of Livestock Products Technology – Diary Science, Veterinary College and Research Institute, Namakkal, Tamil Nadu, INDIA.
CORRESPONDENCE
Singaravel Sengottuvelu
Department of Pharmacology, Nandha College of Pharmacy, Erode, Tamil Nadu, INDIA.
Received: 24-09-2022; Revised: 13-10-2022; Accepted: 28-10-2022.
Volume 11, Issue 3 · pp. 765-768 · 2023 · DOI: 10.5530/ajbls.2022.11.102
ABSTRACT
Aim/Background: The present study was conducted to assess the larvicidal potential of Andrographis echioides against the dengue vector Aedes aegypti larvae. Alcoholic leaf extract of Andrographis echioides was studied at 500, 250, 125, 62.5, 31.25, and 15.625 ppm concentrations against third-instar larvae of Aedes aegypti.Materials and Methods: 100 larvae of Aedes aegypti mosquitoes were exposed to each concentration of both ethanolic and methanolic crude extract of Andrographis echioides in a volume of 100ml. To minimize the error, five replicates were employed with respective diluted alcoholic solutions as control. The percentage mortality of larvae at different concentrations of both alcoholic extracts and control were recorded after 24 hr and 48 hr of constant exposure, followed by LC50 and LC90 determined.Results: The effective and highest coefficient of determination (R2) was calculated using regression analysis. The effective and highest coefficient of determination (R2) was 0.88 in 24 hr of exposure of larvae in methanolic leaf extract of Andrographis echioides. Similarly, the effective and highest coefficient of determination (R2) was 0.94 in 24 hr of exposure larvae in ethanolic leaf extract of Andrographis echioides.Conclusion: From the result, it was concluded that both methanolic and ethanolic leaf extract of Andrographis echioides exhibited larvicidal activity against the dengue vector Aedes aegypti larvae, and it may be due to its secondary metabolite diterpenoid lactone. Further studies may be needed to expose its exact mechanism of action.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Sengottuvelu, S., Sherief, S. H., Mark, J. S., Kathirvelan, C., & Senthamaraikannan, B. (2023). Preliminary Larvicidal Potential of Andrographis Echioides against Dengue Vector Aedes aegypti Larvae. Asian Journal of Biological and Life Sciences, 11(3), 765-768. https://doi.org/10.5530/ajbls.2022.11.102
Copyright and licence
© 2023 Author(s)
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0