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Antioxidant and Cytotoxic agent from Acacia catechu Stem Bark against MCF-7 Cell Line

1, 2

  1. 1Department of Zoology, Annamalai University, Annamalai Nagar, Chidhambaram, Tamil Nadu, INDIA.
  2. 2Department of Zoology, University of Madras Guindy Campus, Chennai, Tamil Nadu, INDIA.

CORRESPONDENCE

Kanayaian Pugazhendy

Department of Zoology, University of Madras Guindy Campus, Chennai, Tamil Nadu, INDIA.

pugalendy@gmail.com

Received: 12-02-2022; Revised: 22-03-2022; Accepted: 05-04-2022.

Volume 11, Issue 1 · pp. 77-81 · 2022 · DOI: 10.5530/ajbls.2022.11.11

ABSTRACT

Anti-cancer agents can be found in a variety of natural products because of their chemical and biological activity. Free radicals are molecules with high instability which induced initiation and progression of tumor formation. In contrast, the compositions of antioxidant material act as defense activator against free radical formation. In the present investigation, we prepared six different methanolic Fractions viz Fractions 1, Fractions 2. Fractions 3, Fractions 4, Fractions5 and Fractions 6 from the methanolic extract of Acacia catechu stem bark. Then we check the in vitro antioxidant activity of different extracted fractions compared with standard ascorbic acid. Based on the high potent antioxidant capacity Fraction 3 were further evaluated the antiproliferative effect on MCF-7 breast cancer cell line. However, MTT assay revealed that, methanolic extracted Fractions 3 had potent cytotoxic effects on MCF-7 cells in the IC50 value at 49.86μg/mL. The study suggested that, the isolated Fraction 3 form the stem bark of Acacia catechu act as preventive agent for free radical formation and also cytotoxicity effect on MCF- 7 cell line under laboratory condition.

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    Sasikala, P., & Pugazhendy, K. (2022). Antioxidant and Cytotoxic agent from Acacia catechu Stem Bark against MCF-7 Cell Line. Asian Journal of Biological and Life Sciences, 11(1), 77-81. https://doi.org/10.5530/ajbls.2022.11.11

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    © 2022 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0